If you already run a BLAKE2b Knots node

Keep your existing Bitcoin data folder. You do not need to download the chain again or move your coins.

If you are still on Bitcoin Core or older Knots

Install a Knots version that includes the BLAKE2b change. RC5 binaries are in the test directory on the mainnet solo mining guide. They are not the published files on bitcoinknots.org. Source is at github.com/bitcoinknots/bitcoin. Your current software may have followed the legacy SHA256d chain. On startup, this release usually notices those extra blocks, walks back to the fork, and then downloads the BLAKE2b chain.

A pruned node deletes old blocks to save disk space. If you waited so long that those walk-back blocks are already gone, or the node followed invalid blocks after a late upgrade, rebuild the node and download the chain again. This release may ask at startup whether that resync is required.

Everyone